Between now and 2020 we are likely to see somewhere between 2 to 3 global pandemics. Several years ago the pandemic of Avian flu began in Asia; today the world faces the Swine flu that can be traced back to central and south America. And tomorrow? In general these pandemics arise in areas that do not have the top tier of preventative or public health infrastructure and, from there, spread to the advanced Western countries. And our ability to achieve global bio-surveillance for disease is limited because of unequal infrastructure, inadequate local investments and only limited global cooperation. So issue number one is bio-surveillance and adequacy of public health infrastructure.